Targeted solid phase fermentation of the soil dwelling fungus Gymnascella dankaliensis yields new brominated tyrosine-derived alkaloids

Author:

Wang Hao1234,Dai Haofu56789,Heering Christian101134,Janiak Christoph101134ORCID,Lin Wenhan12131415,Orfali Raha S.1617181920,Müller Werner E. G.2122234,Liu Zhen1234,Proksch Peter1234

Affiliation:

1. Institute of Pharmaceutical Biology and Biotechnology

2. Heinrich-Heine-Universität Düsseldorf

3. 40225 Düsseldorf

4. Germany

5. Key Laboratory of Biology and Genetic Resources of Tropical Crops

6. Ministry of Agriculture

7. Institute of Tropical Bioscience and Biotechnology

8. Chinese Academy of Tropical Agricultural Sciences

9. Haikou 571101

10. Institute of Inorganic and Structural Chemistry

11. Heinrich-Heine-University Düsseldorf

12. State Key Laboratory of Natural and Biomimetic Drugs

13. Peking University

14. Beijing 100191

15. China

16. Department of Pharmacognosy

17. Faculty of Pharmacy

18. King Saud University

19. Riyadh

20. Saudi Arabia

21. Institut für Physiologische Chemie

22. Universitätsmedizin der Johannes Gutenberg-Universität Mainz

23. 55128 Mainz

Abstract

Seven new brominated alkaloids, gymnastatins T–Y (1–6) and dankastatin D (7), together with three known analogues were isolated from the soil fungus Gymnascella dankaliensis through fermentation on solid rice mediumcontaining NaBr.

Funder

Bundesministerium für Bildung und Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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