Supramolecular chemotherapeutic drug constructed from pillararene-based supramolecular amphiphile-Reference-Cited by-同舟云学术

Supramolecular chemotherapeutic drug constructed from pillararene-based supramolecular amphiphile

Published:2018 Issue:59 Volume:54 Page:8198-8201
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Wu Dan¹²³⁴^ORCID,Li Yang¹²³⁴,Shen Jie⁵⁶⁷⁴,Tong Zaizai⁸⁹¹⁰¹¹¹²^ORCID,Hu Qinglian¹³¹⁴¹⁵⁴,Li Liping¹⁶¹⁷¹⁸¹⁹²⁰,Yu Guocan¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Zhejiang University

3. Hangzhou 310027

4. P. R. China

5. School of Medicine

6. Zhejiang University City College

7. Hangzhou 310015

8. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT)

9. Ministry of Education

10. Department of Materials Science and Engineering

11. Zhejiang Sci-Tech University

12. Hangzhou 310018

13. College of Biotechnology and Bioengineering

14. Zhejiang University of Technology

15. Hangzhou 310014

16. Section on Medical Neuroendocrinology

17. Eunice Kennedy Shriver National Institute of Child Health and Human Development

18. National Institutes of Health

19. Bethesda

20. USA

Abstract

A therapeutic supramolecular amphiphile, P5⊃CPT-ss-Py, with GSH-responsiveness was constructed using pillar[5]arene-based host–guest molecular recognition. Cellular internalization and anticancer efficacy were greatly increased through this supramolecular strategy.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC04334E

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