Selenoprotein H mediates low selenium-related cognitive decline through impaired oligodendrocyte myelination with disrupted hippocampal lipid metabolism in female mice-Reference-Cited by-同舟云学术

Selenoprotein H mediates low selenium-related cognitive decline through impaired oligodendrocyte myelination with disrupted hippocampal lipid metabolism in female mice

Published:2024 Issue:16 Volume:15 Page:8544-8561
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Lv Qingqing¹^ORCID,Yang Aolin¹^ORCID,Han Ziyu¹,Yu Ruirui¹,Zhu Junying¹,Shi Zhan¹,Yang Chenggang¹,Dai Shimiao¹,Hao Mengru¹,Chen Yuqing¹,Zhou Ji-Chang¹²³^ORCID

Affiliation:

1. School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, Guangdong, China

2. Guangdong Province Engineering Laboratory for Nutrition Translation, Shenzhen 518107, Guangdong, China

3. Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Guangzhou 510080, Guangdong, China

Abstract

This study utilizing Selenoh gene knockout mice identified that Selenoh mediates low selenium-related cognitive decline in female mice, an effect attributed to impaired oligodendrocyte myelination with disrupted lipid metabolism in the hippocampus.

Funder

Science, Technology and Innovation Commission of Shenzhen Municipality

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FO/D4FO00888J

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