Cholesterol suppresses membrane leakage by decreasing water penetrability
Author:
Affiliation:
1. Biomechanics and Biomaterials Laboratory
2. Department of Applied Mechanics
3. Beijing Institute of Technology
4. Beijing 100081
5. China
6. Department of Cancer Biology
7. University of Cincinnati College of Medicine
8. Cincinnati
9. USA
Abstract
In silico simulations and biochemical experiments show that cholesterol decreases water penetrability to inhibit leakage pore formation during membrane fusion.
Funder
National Natural Science Foundation of China
Ministry of Science and Technology of the People's Republic of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Condensed Matter Physics,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/SM/C8SM00644J
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