Protein–protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose

Protein–protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose–responses

Published:2015 Issue:10 Volume:11 Page:2750-2762
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Varusai Thawfeek M.¹²³⁴,Kolch Walter¹²³⁴⁵,Kholodenko Boris N.¹²³⁴⁵,Nguyen Lan K.¹²³⁴⁶

Affiliation:

1. Systems Biology Ireland

2. University College Dublin

3. Belfield

4. Ireland

5. Conway Institute

6. Department of Biochemistry and Molecular Biology

Abstract

Our work reveals that simple reversible protein–protein interactions, when embedded into signalling cascades, give rise to extremely rich and complex regulatory dynamics in the absence of explicit positive and negative feedbacks.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C5MB00385G

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