Long-term retention of gold nanoparticles in the liver is not affected by their physicochemical characteristics-Reference-Cited by-同舟云学术

Long-term retention of gold nanoparticles in the liver is not affected by their physicochemical characteristics

Published:2023 Issue:19 Volume:15 Page:8740-8753
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Fernandez Alarcon Jennifer¹^ORCID,Soliman Mahmoud²³^ORCID,Lüdtke Tanja Ursula⁴,Clemente Eva²^ORCID,Dobricic Marko²,Violatto Martina B.¹^ORCID,Corbelli Alessandro¹,Fiordaliso Fabio¹^ORCID,Cordiglieri Chiara⁵^ORCID,Talamini Laura¹^ORCID,Sitia Giovanni⁶^ORCID,Moya Sergio⁴^ORCID,Bigini Paolo¹^ORCID,Monopoli Marco P.²^ORCID

Affiliation:

1. Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milano, Italy

2. Department of Chemistry, Royal College of Surgeons of Ireland RCSI, St Stephens Green 123, Dublin, Ireland

3. Physics Department, Faculty of Science, Al-Azhar University, Cairo, Egypt

4. Department of Soft Matter Nanotechnology, CIC Biomagune, Paseo Miramon 182, 20014 San Sebastian-Donostia, Spain

5. INGM Imaging Facility, Istituto Nazionale Genetica Molecolare, Via Francesco Sforza 35, 20122 Milano, Italy

6. Experimental Hepatology Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy

Abstract

Gold nanoparticles’ tropism towards the liver is affected by their size and aspect ratio, being co-localised inside the lysosomes of hepatic cells, without changes in their morphology or arising liver toxicity after 47 days of administration.

Funder

H2020 Marie Skłodowska-Curie Actions

Associazione Italiana per la Ricerca sul Cancro

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NR/D3NR00685A

Reference46 articles.

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