Modulation of collective cell behaviour by geometrical constraints

Author:

Lunova Mariia123,Zablotskii Vitalii423,Dempsey Nora M.56789,Devillers Thibaut56789,Jirsa Milan123,Syková Eva1023,Kubinová Šárka423102,Lunov Oleg423,Dejneka Alexandr423

Affiliation:

1. Institute for Clinical & Experimental Medicine (IKEM)

2. Prague

3. Czech Republic

4. Institute of Physics of the Academy of Sciences of the Czech Republic

5. Univ. Grenoble Alpes

6. Inst NEEL

7. F-38042 Grenoble

8. France

9. CNRS

10. Institute of Experimental Medicine AS CR

Abstract

During tissue development and growth, cell colonies may exhibit a wide variety of exquisite spatial and temporal patterns. We demonstrated that the geometrical confinement caused by topographically patterned substrates modulates cell and nuclear morphology and collective cellular behavior.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

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