Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae-Reference-Cited by-同舟云学术

Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae

Published:2018 Issue:51 Volume:54 Page:6995-6998
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Perera Namal¹²³⁴⁵^ORCID,Yang Feng-Ling¹²³⁴^ORCID,Chern Jeffy¹²³⁴⁵^ORCID,Chiu Hsiao-Wen⁶⁷³⁴⁸,Hsieh Chih-Yu⁸⁹¹⁰⁴^ORCID,Li Lan-Hui¹¹¹²¹³³⁴,Zhang Yan-Long¹⁴¹⁵¹⁶¹⁷¹⁸,Hua Kuo-Feng⁸⁹¹⁰⁴¹⁹^ORCID,Wu Shih-Hsiung¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Biological Chemistry

2. Academia Sinica

3. Taipei

4. Taiwan

5. Chemical Biology and Molecular Biophysics Program

6. Graduate Institute of Life Sciences

7. National Defense Medical Center

8. Department of Biotechnology and Animal Science

9. National Ilan University

10. Ilan

11. Department of Laboratory Medicine, Linsen

12. Chinese Medicine and Kunming Branch

13. Taipei City Hospital

14. Key Laboratory of Molecular Biology of Heilongjiang Province

15. College of Life Sciences

16. Heilongjiang University

17. Harbin 150080

18. China

19. Department of Pathology

Abstract

O-acetyl and carboxylic functionalities of Auricularia auricula-judae glucuronoxylomannan play critical roles in TLR4/MD2 receptor binding for its immunostimulatory activity.

Funder

Ministry of Science and Technology

Academia Sinica

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C7CC09927D

Reference21 articles.

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5. Evaluation of water soluble β-d-glucan from Auricularia auricular-judae as potential anti-tumor agent

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