A phosphorylated zinc finger peptide bearing a gadolinium complex for zinc detection by MRI-Reference-Cited by-同舟云学术

A phosphorylated zinc finger peptide bearing a gadolinium complex for zinc detection by MRI

Published:2023 Issue:19 Volume:52 Page:6260-6266
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Malikidogo Kyangwi P.¹^ORCID,Pallier Agnès²,Szeremeta Frédéric²,Bonnet Célia S.²^ORCID,Sénèque Olivier¹^ORCID

Affiliation:

1. Univ. Grenoble Alpes, CNRS, CEA, IRIG, LCBM (UMR 5249), F-38000 Grenoble, France

2. Centre de Biophysique Moléculaire, CNRS (UPR 4301), Université d'Orléans, F-45041 Orléans, France

Abstract

The MRI efficacy of the zinc finger peptide is greatly increased upon zinc binding thanks to a combination of reversible binding of phosphoserine to Gd3+ and increased rigidity. This versatile system is highly sensitive to small amino acid changes.

Funder

Ligue Contre le Cancer

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/DT/D3DT00728F

Reference28 articles.

1. A Bioinorganic View of Alzheimer’s Disease: When Misplaced Metal Ions (Re)direct the Electrons to the Wrong Target

2. Recent Advances in Zinc Enzymology

3. Role of Zinc Signaling in the Regulation of Mast Cell-, Basophil-, and T Cell-Mediated Allergic Responses

4. Quantitative mapping of zinc fluxes in the mammalian egg reveals the origin of fertilization-induced zinc sparks

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