De novo glycan sequencing by electronic excitation dissociation MS2-guided MS3 analysis on an Omnitrap-Orbitrap hybrid instrument-Reference-Cited by-同舟云学术

De novo glycan sequencing by electronic excitation dissociation MS²-guided MS³ analysis on an Omnitrap-Orbitrap hybrid instrument

Published:2023 Issue:24 Volume:14 Page:6695-6704
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wei Juan¹²^ORCID,Papanastasiou Dimitris³,Kosmopoulou Mariangela³,Smyrnakis Athanasios³^ORCID,Hong Pengyu⁴^ORCID,Tursumamat Nafisa¹,Klein Joshua A.²,Xia Chaoshuang²^ORCID,Tang Yang²⁵,Zaia Joseph²^ORCID,Costello Catherine E.²⁵^ORCID,Lin Cheng²^ORCID

Affiliation:

1. Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China

2. Center for Biomedical Mass Spectrometry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA

3. Fasmatech Science and Technology, 15310 Athens, Greece

4. Department of Computer Science, Brandeis University, Waltham, MA 02454, USA

5. Department of Chemistry, Boston University, Boston, MA 02215, USA

Abstract

EED MS2 spectra were used to generate candidate topologies and guide selection of fragment(s) for MS3 analysis. Isotoplogies indistinguishable at the MS2 level may be differentiated by CID-EED MS3 analysis.

Funder

National Center for Research Resources

National Institute of General Medical Sciences

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC00870C

Reference62 articles.

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