Copper (Cu2+) ion-induced misfolding of tau protein R3 peptide revealed by enhanced molecular dynamics simulation-Reference-Cited by-同舟云学术

Copper (Cu2+) ion-induced misfolding of tau protein R3 peptide revealed by enhanced molecular dynamics simulation

Author:

Jing Jing¹²³⁴⁵,Tu Gao⁵⁶⁷⁸⁴,Yu Hongyan¹²³⁴⁵,Huang Rong⁹¹⁰⁴¹¹¹⁰,Ming Xianquan¹²¹³⁴,Zhan Haiqing¹²¹³⁴,Zhan Feng¹²³⁴,Xue Weiwei⁵⁶⁷⁸⁴^ORCID

Affiliation:

1. The Key Laboratory of Nonferrous Metal Materials and New Processing Technology of Ministry of Education

2. Guangxi University

3. Nanning 530004

4. China

5. School of Pharmaceutical Sciences and Innovative Drug Research Centre

6. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research

7. Chongqing University

8. Chongqing 401331

9. Central Nervous System Drug Key Laboratory of Sichuan Province

10. Luzhou 646106

11. Sichuan Credit Pharmaceutical Co., Ltd.

12. CITIC Dameng Mining Industries Ltd.

13. Nanning 530028

Abstract

Tau misfolding plays a significant role in some neurodegenerative diseases such as Alzheimer's disease (AD).

Funder

Natural Science Foundation of Guangxi Province

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

Reference51 articles.

3. Y. H. Hung , A. I.Bush and R. A.Cherny , Copper and Alzheimer Disease: The Good, the Bad and the Ugly , Springer New York , 2012

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