Maternal exposure to polystyrene nanoplastics impacts developmental milestones and brain structure in mouse offspring

Author:

Harvey Nikita E.1,Mercer Grace V.1,Stapleton Darcie1,Steeves Katherine L.1,Hanrahan Jenna1,Cui Megan1,Aghaei Zahra1,Spring Shoshana2,Helm Paul A.3,Simpson André J.4ORCID,Simpson Myrna J.4ORCID,Macgowan Christopher K.56,Baschat Ahmet A.7,Kingdom John C.89,Sled John G.2568,Jobst Karl J.1,Cahill Lindsay S.110ORCID

Affiliation:

1. Department of Chemistry, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, A1C5S7, Canada

2. Mouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, Canada

3. School of the Environment, University of Toronto, Toronto, Ontario, Canada

4. Environmental NMR Centre and Department of Physical and Environmental Sciences, University of Toronto, Toronto, Ontario, Canada

5. Translational Medicine, Hospital for Sick Children, Toronto, Ontario, Canada

6. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

7. Johns Hopkins Center for Fetal Therapy, Department of Gynecology & Obstetrics, Johns Hopkins University, Baltimore, MD, USA

8. Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada

9. Department of Obstetrics and Gynecology, Mount Sinai Hospital, Toronto, Ontario, Canada

10. Discipline of Radiology, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada

Abstract

Maternal exposure to polystyrene nanoplastics impact postnatal brain development in mouse offspring. This work motivates further studies to determine the levels of nanoplastics in the environment.

Publisher

Royal Society of Chemistry (RSC)

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