Spermine-starch nanoparticles with antisense <i>vicR</i> suppress <i>Streptococcus mutans</i> cariogenicity-Reference-Cited by-同舟云学术

Spermine-starch nanoparticles with antisense vicR suppress Streptococcus mutans cariogenicity

Published:2023 Issue:25 Volume:11 Page:5752-5766
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Lei Lei¹,Zhang Yue¹,Xu Yichen²,Tian Yuting¹,Zhao Jialiang¹,Xiang Yong¹,Yang Huiyu¹,Yang Yingming¹,Hu Tao¹^ORCID

Affiliation:

1. State Key Laboratory of Oral Diseases, Department of Preventive Dentistry, West China Hospital of Stomatology, Sichuan University, 14# Third Section Renmin South Road, Chengdu, 610041, China

2. State Key Laboratory of Oral Diseases, Department of Oral Prosthodontics, West China Hospital of Stomatology, Sichuan University, 14# Third Section Renmin South Road, Chengdu, 610041, China

Abstract

We developed SSN nanovector for ASvicR delivery using natural starch spermine to protect ASvicR from nuclease degradation and achieve high transformation efficiency, inhibit EPS and cariogenicity of S. mutans, maintain oral flora homeostasis.

Funder

National Natural Science Foundation of China

Sichuan Province Science and Technology Support Program

West China School of Stomatology, Sichuan University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2023/TB/D2TB02628G

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