Synthesis of optically active 2-substituted azetidine-2-carbonitriles from chiral 1-arylethylamine via α-alkylation of N-borane complexes-Reference-Cited by-同舟云学术

Synthesis of optically active 2-substituted azetidine-2-carbonitriles from chiral 1-arylethylamine via α-alkylation of N-borane complexes

Published:2021 Issue:38 Volume:11 Page:23825-23837
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Tayama Eiji¹²³⁴⁵^ORCID,Nakanome Nobuhiro⁶³⁴⁵

Affiliation:

1. Department of Chemistry

2. Faculty of Science

3. Niigata University

4. Niigata

5. Japan

6. Graduate School of Science and Technology

Abstract

Synthesis of optically active 2-substituted azetidine-2-carbonitriles by LDA-promoted diastereoselective α-alkylation of borane N-((S)-1-arylethyl)azetidine-2-carbonitrile complexes was demonstrated.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA04585G

Reference38 articles.

1. Azetidines and their applications in asymmetric catalysis

2. Ring‐opening of azetidiniums by nucleophiles. Synthesis of polysubstituted linear amines

3. Use of azetidine scaffolds in stereoselective transformations (microreview)

4. Recent advances in synthetic facets of immensely reactive azetidines

5. Recent advances in the chemistry of metallated azetidines

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