Millifluidic magnetophoresis-based chip for age-specific fractionation: evaluating the impact of age on metabolomics and gene expression in yeast-Reference-Cited by-同舟云学术

Millifluidic magnetophoresis-based chip for age-specific fractionation: evaluating the impact of age on metabolomics and gene expression in yeast

Published:2024 Issue:11 Volume:24 Page:2987-2998
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Wittmann L.¹^ORCID,Eigenfeld M.²³^ORCID,Büchner K.²^ORCID,Meiler J.¹,Habisch H.³^ORCID,Madl T.³⁴^ORCID,Kerpes R.²^ORCID,Becker T.³⁵^ORCID,Berensmeier S.¹⁵^ORCID,Schwaminger S. P.¹³⁴^ORCID

Affiliation:

1. TUM School of Engineering and Design, Chair of Bioseparation Engineering, Technical University of Munich, Boltzmannstr. 15, 85748 Garching, Germany

2. TUM School of Life Science, Chair of Brewing and Beverage Technology, Technical University of Munich, Weihenstephaner Steig 20, 85354 Freising, Germany

3. Otto-Loewi Research Center, Division of Medicinal Chemistry, Medical University of Graz, Neue Stiftingtalstr. 6, 8010 Graz, Austria

4. BioTechMed-Graz, Mozartgasse 12/II, 8010 Graz, Austria

5. Munich Institute of Integrated Materials, Energy and Process Engineering, Technical University of Munich, Lichtenberstr. 4a, 85748 Garching, Germany

Abstract

A novel millifluidic magnetophoresis approach can be used to fractionate yeast cells according to their individual cell age. Old and young cells show different behavior in gene expression and their metabolome.

Funder

Deutsche Forschungsgemeinschaft

Austrian Science Fund

Österreichische Forschungsförderungsgesellschaft

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/LC/D4LC00185K

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