Mass defect-based carbonyl activated tags (mdCATs) for multiplex data-independent acquisition proteome quantification

Author:

Zhang Siwen1234,Di Yi1234,Yao Jun1234,Wang Yingjie56789,Shu Hong1011124,Yan Guoquan1234,Zhang Lei1234,Lu Haojie123413ORCID

Affiliation:

1. Shanghai Cancer Center and Institutes of Biomedical Sciences

2. Fudan University

3. Shanghai 200032

4. China

5. State Key Laboratory of Bioorganic and Natural Products Chemistry

6. Center for Excellence in Molecular Synthesis

7. Shanghai Institute of Organic Chemistry

8. University of Chinese Academy of Sciences

9. Chinese Academy of Sciences

10. Department of Clinical Laboratory

11. Cancer Hospital of Guangxi Medical University

12. Nanning

13. Department of Chemistry and NHC Key Laboratory of Glycoconjugates Research

Abstract

A novel eight-plex mass-defect-based carbonyl activated tag (mdCAT) has been designed for DIA quantification for the first time.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Science and Technology Commission of Shanghai Municipality

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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