Acid-labile polysaccharide prodrug via lapatinib-sensitizing effect substantially prevented metastasis and postoperative recurrence of triple-negative breast cancer-Reference-Cited by-同舟云学术

Acid-labile polysaccharide prodrug via lapatinib-sensitizing effect substantially prevented metastasis and postoperative recurrence of triple-negative breast cancer

Published:2020 Issue:25 Volume:12 Page:13567-13581
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Sui Junhui¹²³⁴,Zhao Mingda¹²³⁴,Yang Yuedi¹²³⁴,Guo Zhihao⁵⁶⁷⁸⁴,Ma Mengcheng¹²³⁴,Xu Zhiyi¹²³⁴,Liang Jie¹²³⁴,Sun Yong¹²³⁴^ORCID,Fan Yujiang¹²³⁴^ORCID,Zhang Xingdong¹²³⁴

Affiliation:

1. National Engineering Research Center for Biomaterials

2. Sichuan University

3. Chengdu

4. China

5. Center for Molecular Science and Engineering

6. College of Science

7. Northeastern University

8. Shenyang 110819

Abstract

Co-delivery of lapatinib and Dox by polysaccharide prodrug prevented metastasis and recurrence of triple-negative breast cancer (TNBC) that is usually insensitive to endocrine and molecular targeted therapy.

Funder

National Natural Science Foundation of China

China Association for Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NR/D0NR03395B

Reference49 articles.

1. Triple-Negative Breast Carcinoma

2. Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease