Synthesis and biological evaluation of hybrids from farnesylthiosalicylic acid and hydroxylcinnamic acid with dual inhibitory activities of Ras-related signaling and phosphorylated NF-κB-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of hybrids from farnesylthiosalicylic acid and hydroxylcinnamic acid with dual inhibitory activities of Ras-related signaling and phosphorylated NF-κB

Published:2014 Issue:25 Volume:12 Page:4517-4530
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ling Yong¹²³⁴⁵,Wang Zhiqiang¹²³⁴⁵,Wang Xuemin¹²³⁴,Zhao Ying¹²³⁴,Zhang Wei¹²³⁴,Wang Xinyang¹²³⁴,Chen Li⁵⁶⁷⁴⁸,Huang Zhangjian⁵⁶⁷⁴⁸,Zhang Yihua⁵⁶⁷⁴⁸

Affiliation:

1. School of Pharmacy

2. Nantong University

3. Nantong

4. PR China

5. State Key Laboratory of Natural Medicines

6. China Pharmaceutical University

7. Nanjing

8. Center of Drug Discovery

Abstract

Hybrid 5f significantly inhibited both Ras-related signaling and phosphorylated NF-κB, which may synergistically contribute to its apoptosis induction and tumor growth inhibition in vitro and in vivo.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00023D

Reference25 articles.

1. The Guanine Nucleotide-Binding Switch in Three Dimensions

2. The Ras superfamily at a glance

3. The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

4. Targeting RAS signalling pathways in cancer therapy

5. Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

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