PI3K/AKT/mTOR signaling regulates BCP ceramic-induced osteogenesis-Reference-Cited by-同舟云学术

PI3K/AKT/mTOR signaling regulates BCP ceramic-induced osteogenesis

Published:2024 Issue:31 Volume:12 Page:7591-7603
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Tan Peijie¹,Hua Yuchen¹,Yuan Bo¹,Liu Xiaoyang²,Chen Xuening¹^ORCID,Zeng Wei-Nan²^ORCID,Zeng Qin¹³^ORCID,Zhu Xiangdong¹^ORCID,Zhang Xingdong¹³

Affiliation:

1. National Engineering Research Center for Biomaterials, Sichuan University, No. 29 Wangjiang Road, Chengdu 610064, China

2. Orthopedic Research Institution, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, China

3. NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterials & Institute of Regulatory Science for Medical Devices & NMPA Research Base of Regulatory Science for Medical Devices, Sichuan University, Chengdu 610064, China

Abstract

BCP ceramics regulate PI3K/AKT/mTOR signaling for cell proliferation and osteogenic gene expression of BMSCs in vitro and new ectopic bone formation in the implanted ceramics in mice.

Funder

National Natural Science Foundation of China

Sichuan Province Science and Technology Support Program

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/TB/D4TB01335B

Reference40 articles.

1. Deciphering the combined effect of bone morphogenetic protein 6 and calcium phosphate on bone formation capacity of periosteum derived cell-based tissue engineering constructs

2. Biphasic calcium phosphate ceramics for bone reconstruction: A review of biological response

3. Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms

4. The material and biological characteristics of osteoinductive calcium phosphate ceramics