Metal-free synthesis of 2,2-disubstituted indolin-3-ones-Reference-Cited by-同舟云学术

Metal-free synthesis of 2,2-disubstituted indolin-3-ones

Published:2019 Issue:8 Volume:17 Page:2199-2203
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Jiang Xinpeng¹²³⁴^ORCID,Zhu Bingbin⁵²³⁴,Lin Kai⁵²³⁴,Wang Guan¹²³⁴,Su Wei-Ke⁵²³⁴^ORCID,Yu Chuanming¹²³⁴⁵^ORCID

Affiliation:

1. College of Pharmaceutical Sciences

2. Zhejiang University of Technology

3. Hangzhou

4. P.R. China

5. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals

Abstract

A straightforward method for the synthesis of indolin-3-ones bearing a C2-quaternary functionality is reported. This cross-coupling reaction allows the facile synthesis of a series of 2,2-disubstituted indolin-3-ones in the absence of a metal catalyst in up to 94% yields.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB03057J

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1. Total Synthesis of Complex Cyclotryptamine Alkaloids: Stereocontrolled Construction of Quaternary Carbon Stereocenters

2. Total Synthesis of (+)-Isatisine A

3. Austamide, a new toxic metabolite from