Fostering protein–calixarene interactions: from molecular recognition to sensing

Author:

Prata José V.12345,Barata Patrícia D.12345

Affiliation:

1. Laboratório de Química Orgânica

2. Departamento de Engenharia Química and Centro de Investigação de Engenharia Química e Biotecnologia

3. Instituto Superior de Engenharia de Lisboa

4. Instituto Politécnico de Lisboa

5. Lisboa

Abstract

An highly selective direct sensing of cytochrome c by a bis-calix[4]arene-carbazole conjugate (CCC-1) in aqueous-based medium at nanomolar levels is disclosed. An electron transfer (ET) between complexed partners mediates the sensory event.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference69 articles.

1. Calixarenes 2001, ed. Z. Asfari, V. Böhmer, J. Harrowfield and J. Vicens, Kluwer Academic, Dordrecht, 2001

2. C. D. Gutsche , Calixarenes: An Introduction – Monographs in Supramolecular Chemistry, ed. J. F. Stoddart, The Royal Society of Chemistry, Cambridge, 2nd edn, 2008

3. J. W. Steed and J. L.Atwood, Supramolecular Chemistry, John Wiley & Sons, Chichester, 2nd edn, 2009

4. Protein surface recognition and proteomimetics: mimics of protein surface structure and function

5. Strategies for Targeting Protein-Protein Interactions With Synthetic Agents

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