Inhibition of thrombin activity by a covalent-binding aptamer and reversal by the complementary strand antidote-Reference-Cited by-同舟云学术

Inhibition of thrombin activity by a covalent-binding aptamer and reversal by the complementary strand antidote

Published:2021 Issue:20 Volume:57 Page:2483-2486
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Tabuchi Yudai¹²³⁴⁵,Yang Jay⁶⁷⁸⁹¹⁰^ORCID,Taki Masumi¹²³⁴⁵^ORCID

Affiliation:

1. Department of Engineering Science, Bioscience and Technology Program

2. The Graduate School of Informatics and Engineering

3. The University of Electro-Communications (UEC)

4. Tokyo 182-8585

5. Japan

6. Department of Anesthesiology

7. University of Wisconsin

8. School of Medicine and Public Health

9. Madison

10. USA

Abstract

We created a DNA-aptamer-type covalent drug where the pharmacological effect can be reversed by the complementary strand antidote.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D0CC08109D

Reference41 articles.

1. Targeted Covalent Inhibitors for Drug Design

2. Drug–Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization

3. Beyond Picomolar Affinities: Quantitative Aspects of Noncovalent and Covalent Binding of Drugs to Proteins

4. Strategies for discovering and derisking covalent, irreversible enzyme inhibitors

5. Covalent inhibitors: an opportunity for rational target selectivity

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