One-pot synthesis of 3-hydroxy-2-oxindoles via acyloin rearrangements of 2-hydroxy-indolin-3-ones generated in situ from 2-alkynyl arylazides
Author:
Affiliation:
1. Co-Innovation Center for Efficient Processing and Utilization of Forest Products
2. College of Chemical Engineering
3. Nanjing Forestry University
4. Nanjing 210037
5. China
Abstract
A novel one-pot method to prepare 3-hydroxy-2-oxindoles via acyloin rearrangements of 2-hydroxy-indolin-3-ones generated in situ from 2-alkynyl arylazides has been described.
Funder
Natural Science Foundation of Jiangsu Province
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Materials Chemistry,General Chemistry,Catalysis
Link
http://pubs.rsc.org/en/content/articlepdf/2020/NJ/D0NJ04588H
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1. 3-Substituted-3-hydroxy-2-oxindole, an Emerging New Scaffold for Drug Discovery with Potential Anti-Cancer and other Biological Activities
2. Pharmacological profile of a new orally active growth hormone secretagogue, SM-130686
3. Design, Synthesis and Pharmacological Evaluation of HIV-1 Reverse Transcriptase Inhibition of New Indolin-2-Ones
4. DISCOVERY OF A NOVEL CLASS OF BK CHANNEL OPENERS: ENANTIOSPECIFIC SYNTHESIS AND BK CHANNEL OPENING ACTIVITY OF 3-(5-CHLORO-2-HYDROXYPHENYL)-1,3-DIHYDRO-3-HYDROXY-6-(TRIFLUOROMETHYL)-2H-INDOL-2-ONE
5. The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis
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