Silkworm spinning inspired 3D printing toward a high strength scaffold for bone regeneration

Author:

Yao Yingkai1,Guan Diqin1ORCID,Zhang Chenke2,Liu Jing1,Zhu Xufeng1,Huang Tingting3,Liu Jie1ORCID,Cui Hongjuan4,Tang Kang-lai2,Lin Jinxin3,Li Fengyu15ORCID

Affiliation:

1. College of Chemistry and Materials Science, Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Jinan University, Huangpudadao West No. 601, Tianhe District, Guangzhou 510632, China

2. Sports Medicine Center, Department of Orthopedic Surgery, Southwest Hospital, The Third Military Medical University, Gaotanyan Str. 30, Shapingba District, Chongqing 400038, China

3. Key Laboratory of Optoelectronic Materials Chemistry and Physics, Chinese Academy of Sciences Fujian Institute of Research on the Structure of Matter, 155 Yangqiao Road West, Fuzhou 350002, China

4. Sate Key Laboratory of Silkworm Genome Biology, Southwest University of China, Chongqing, 400715, China

5. College of Chemistry, Zhengzhou University, Zhengzhou 450001, China

Abstract

Inspired by silkworm spinning, we fabricated silk fibroin-hydroxyapatite self-assembling and dense nanostructures composite scaffolds for bone regeneration by 3D printing, and the maximum compressive strength of the scaffold reaches up to 166 MPa.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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