Six-week inhalation of lead oxide nanoparticles in mice affects antioxidant defense, immune response, kidneys, intestine and bones

Author:

Tulinska Jana1,Krivosikova Zora1ORCID,Liskova Aurelia1,Lehotska Mikusova Miroslava1,Masanova Vlasta1,Rollerova Eva2,Stefikova Kornelia1,Wsolova Ladislava2,Babelova Andrea3ORCID,Tothova Lubomira4,Busova Milena5,Babickova Janka46,Uhnakova Iveta1,Alacova Radka2,Dusinska Maria7,Horvathova Mira1,Szabova Michaela1,Vecera Zbynek8,Mikuska Pavel8,Coufalik Pavel8ORCID,Krumal Kamil8,Alexa Lukas8,Piler Pavel9ORCID,Thon Vojtech9,Docekal Bohumil1

Affiliation:

1. Faculty of Medicine, Slovak Medical University, Limbova 12, 833 03 Bratislava, Slovakia

2. Faculty of Public Health, Slovak Medical University, Bratislava, Slovakia

3. Cancer Research Institute, Biomedical Research Centre, Slovak Academy of Sciences, Bratislava, Slovakia

4. Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia

5. Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University, General University Hospital in Prague, Czech Republic

6. Department of Clinical Medicine, University of Bergen, Bergen, Norway

7. Norwegian Institute for Air Research, Health Effects Laboratory, Kjeller, Norway

8. Department of Environmental Analytical Chemistry, Institute of Analytical Chemistry of the Czech Academy of Sciences, Brno, Czech Republic

9. RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic

Abstract

Inhalation of PbO nanoparticles in mice has adverse effects on immune response, oxidative stress, antioxidative defense, kidneys, intestine and bones.

Funder

Grantová Agentura České Republiky

Univerzita Karlova v Praze

European Regional Development Fund

EEA Grants/Norway Grants

Seventh Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

General Environmental Science,Materials Science (miscellaneous)

Reference78 articles.

1. Norkem , Lead Oxide (PbO) Nanoparticles – Properties, Applications , AZoNano , 2013

2. PbO as an efficient and reusable catalyst for one-pot synthesis of tetrahydro benzo pyrans and benzylidene malonitriles

3. H.Abadin , A.Ashizawa , Y. W.Stevens , F.Llados , G.Diamond , G.Sage , M.Citra , A.Quinones , S. J.Bosch and S. G.Swarts , in Toxicological Profile for Lead , Agency for Toxic Substances and Disease Registry (US) , Atlanta, (GA) , 2007

4. Microchemical Investigations of Dust Emitted by a Lead Smelter

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