Theoretical analysis of cargo transport by catch bonded motors in optical trapping assays

Author:

Sundararajan Naren12,Guha Sougata34ORCID,Muhuri Sudipto12,Mitra Mithun K.34ORCID

Affiliation:

1. Department of Physics, Savitribai Phule Pune University, Pune 411007, India

2. Martin Fisher School of Physics, Brandeis University, Waltham, MA 02453, USA

3. Department of Physics, Indian Institute of Technology Bombay, Mumbai 400076, India

4. INFN Napoli, Complesso Universitario di Monte S. Angelo, 80126 Napoli, Italy

Abstract

A theoretical study of cargo transport by dynein motors in an optical trap shows non-trivial transport behaviour due to the dynein catch bond. We compare our model with experimental data to estimate the force scale at which the catch bond sets in.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

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