Formation of EGFRwt/EGFRvIII homo- and hetero-dimers in glioblastoma cells as detected by single molecule localization microscopy-Reference-Cited by-同舟云学术

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Formation of EGFRwt/EGFRvIII homo- and hetero-dimers in glioblastoma cells as detected by single molecule localization microscopy

Published:2024 Issue:32 Volume:16 Page:15240-15255
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Jahnke Kevin¹,Struve Nina²,Hofmann Daniel¹,Gote Martin Julius¹,Bach Margund¹,Kriegs Malte²,Hausmann Michael¹^ORCID

Affiliation:

1. Kirchhoff-Institute for Physics, Heidelberg University, Im Neuenheimer Feld 227, 69120 Heidelberg, Germany

2. Department of Radiotherapy & Radiation Oncology, University Medical Center Hamburg – Eppendorf, Martinistr. 52, 20246 Hamburg, Germany

Abstract

Results for EGFRvIII and EGFRwt localization and dimerization in glioblastoma multiforme cells are shown. The study used single molecule localization microscopy and data processing by Ripley statistics, persistent homology and similarity algorithms.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NR/D4NR01570C

Reference68 articles.

1. Receptor Tyrosine Kinases in the Nucleus

2. Molecular Mechanisms of Epidermal Growth Factor Receptor (EGFR) Activation and Response to Gefitinib and Other EGFR-Targeting Drugs

3. Localisation Microscopy of Breast Epithelial ErbB-2 Receptors and Gap Junctions: Trafficking after γ-Irradiation, Neuregulin-1β, and Trastuzumab Application

4. Clustered localization of EGFRvIII in glioblastoma cells as detected by high precision localization microscopy

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