Polymeric prodrugs conjugated with reduction-sensitive dextran–camptothecin and pH-responsive dextran–doxorubicin: an effective combinatorial drug delivery platform for cancer therapy

Author:

Cao Dongling12345,He Jinlin12345,Xu Jiaying678910,Zhang Mingzu12345,Zhao Lin678910,Duan Guangxin678910,Cao Youwen12345,Zhou Ruhong678910,Ni Peihong12345

Affiliation:

1. College of Chemistry

2. Chemical Engineering and Materials Science

3. State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials

4. Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis

5. Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application

6. School for Radiological & Interdisciplinary Science

7. and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions

8. Soochow University

9. Suzhou 215123

10. P. R. China

Abstract

Two types of stimuli-sensitive polymeric prodrugs for combinatorial cancer therapy have been prepared and found to exhibit favorable anticancer activity in vitro and in vivo.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

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