Total synthesis of two potent anti-inflammatory macrolactones of the oxacyclododecindione type-Reference-Cited by-同舟云学术

Total synthesis of two potent anti-inflammatory macrolactones of the oxacyclododecindione type

Published:2015 Issue:28 Volume:13 Page:7813-7821
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Tauber Johannes¹²³⁴,Rohr Markus⁵⁶⁷⁴,Walter Thorsten⁵⁶⁷⁴,Erkel Gerhard⁵⁶⁷⁴,Opatz Till¹²³⁴

Affiliation:

1. Institute of Organic Chemistry

2. Johannes Gutenberg-University

3. 55128 Mainz

4. Germany

5. Department of Molecular Biotechnology & Systems Biology

6. University of Kaiserslautern

7. 67663 Kaiserslautern

Abstract

The first successful synthetic entry into the highly potent oxacyclododecindione type macrolactones by a late-stage intramolecular Friedel–Crafts cyclization is described.

Funder

Carl-Zeiss-Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01044F

Reference27 articles.

1. 4-Dechloro-14-deoxy-oxacyclododecindione and 14-deoxy-oxacylododecindione, two inhibitors of inducible connective tissue growth factor expression from the imperfect fungus Exserohilum rostratum

2. Oxacyclododecindione, a Novel Inhibitor of IL-4 Signaling from Exserohilum rostratum

3. Synthetic Approaches to Anti-Inflammatory Macrolactones of the Oxacyclododecindione Type

4. Synthesis of (±)-di-O-methylcurvularin

5. 2-(Trimethylsilyl)�thylester als Carboxylschutzgruppe; Anwendung bei der Synthese des (?)-(S)-Curvularins

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