Multi-target-directed phenol–triazole ligands as therapeutic agents for Alzheimer's disease-Reference-Cited by-同舟云学术

Multi-target-directed phenol–triazole ligands as therapeutic agents for Alzheimer's disease

Published:2017 Issue:8 Volume:8 Page:5636-5643
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Jones Michael R.¹²³⁴⁵,Mathieu Emilie¹²³⁴,Dyrager Christine¹²³⁴^ORCID,Faissner Simon⁵⁶⁷⁸⁹,Vaillancourt Zavier¹²³⁴,Korshavn Kyle J.¹¹⁰¹¹¹²,Lim Mi Hee¹¹³¹⁴¹⁵^ORCID,Ramamoorthy Ayyalusamy¹¹⁰¹¹¹²¹⁶^ORCID,Wee Yong V.⁵⁶⁷⁸⁹,Tsutsui Shigeki⁵⁶⁷⁸⁹,Stys Peter K.⁵⁶⁷⁸⁹,Storr Tim¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Simon Fraser University

3. Burnaby

4. Canada

5. Department of Clinical Neurosciences

6. Hotchkiss Brain Institute

7. Cumming School of Medicine

8. University of Calgary

9. Calgary

10. University of Michigan

11. Ann Arbor

12. USA

13. Ulsan National Institute of Science and Technology (UNIST)

14. Ulsan

15. Korea

16. Department of Biophysics

Abstract

A series of multi-target-directed ligands are described that bind Cu, act as antioxidants, modulate Aβ peptide aggregation, and abolish Aβ toxicity in primary neurons.

Funder

Michael Smith Foundation for Health Research

Alzheimer's Association

Brain Canada

Alzheimer's Society of Canada

CIHR

Canada Research Chairs

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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