Continuous-flow, well-mixed, microfluidic crystallization device for screening of polymorphs, morphology, and crystallization kinetics at controlled supersaturation-Reference-Cited by-同舟云学术

Continuous-flow, well-mixed, microfluidic crystallization device for screening of polymorphs, morphology, and crystallization kinetics at controlled supersaturation

Published:2019 Issue:14 Volume:19 Page:2373-2382
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Coliaie Paria¹²³⁴,Kelkar Manish S.⁵⁶⁷⁸⁴,Nere Nandkishor K.⁵⁶⁷⁸⁴,Singh Meenesh R.¹²³⁴^ORCID

Affiliation:

1. Department of Chemical Engineering

2. University of Illinois at Chicago

3. Chicago

4. USA

5. Center of Excellence for Isolation & Separation Technologies (CoExIST)

6. Process R&D

7. AbbVie Inc.

8. North Chicago

Abstract

While the conventional screening techniques suffer from depletion of supersaturation, the continuous-flow microfluidic device screens crystalline materials at controlled supersaturation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2019/LC/C9LC00343F

Reference28 articles.

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2. Polymorphism and Crystallization of Active Pharmaceutical Ingredients (APIs)

3. Screening Crystal Morphologies from Crystal Structure

4. S. R. Byrn , R. R.Pfeiffer and J. G.Stowell , Solid-state chemistry of drugs , SSCI, Inc. , West Lafayette, Ind , 1999

5. Image-Analysis-Based Method for 3D Crystal Morphology Measurement and Polymorph Identification Using Confocal Microscopy

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