Self-targeted, bacillus-shaped, and controlled-release methotrexate prodrug polymeric nanoparticles for intratumoral administration with improved therapeutic efficacy in tumor-bearing mice

Author:

Lin Jinyan12345,Li Yanxiu12345,Li Yang12345,Cui Fei12345,Yu Fei6345,Wu Hongjie78395,Xie Liya10115,Luo Fanghong1213345,Hou Zhenqing12345,Lin Changjian6345

Affiliation:

1. Department of Biomaterials and Department of Materials Science and Engineering

2. College of Materials

3. Xiamen University

4. Xiamen 361005

5. China

6. College of Chemistry and Chemical Engineering

7. Department of Pharmacy

8. School of Pharmaceutical Science

9. Xiamen 361102

10. The First Affiliated Hospital of Xiamen University

11. Xiamen 361002

12. Cancer Research Center

13. Medical College

Abstract

Self-targeted, bacillus-shaped, and controlled-release methotrexate prodrug polymeric nanoparticles for highly efficient cancer chemotherapy: more elongated is better.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Reference55 articles.

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2. R. Stupp , W. P.Mason, M. J.van den Bent, M.Weller, B.Fisher, M. J.Taphoorn, K.Belanger, A. A.Brandes, C.Marosi, U.Bogdahn, J.Curschmann, R. C.Janzer, S. K.Ludwin, T.Gorlia, A.Allgeier, D.Lacombe, J. G.Cairncross, E.Eisenhauer, R. O.Mirimanoff, for the European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups and National Cancer Institute of Canada Clinical Trials Group, N. Engl. J. Med., 2005, 352, 987996

3. A holistic approach to targeting disease with polymeric nanoparticles

4. Convection-enhanced delivery and in vivo imaging of polymeric nanoparticles for the treatment of malignant glioma

5. Topical delivery of anti-TNFα siRNA and capsaicin via novel lipid-polymer hybrid nanoparticles efficiently inhibits skin inflammation in vivo

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