1,2,3-Triazole-fused spirochromenes as potential anti-tubercular agents: synthesis and biological evaluation

Author:

Ashok Dongamanti12345ORCID,Chiranjeevi Pamula12345,Kumar Aamate Vikas12345,Sarasija Madderla265,Krishna Vagolu Siva7895,Sriram Dharmarajan7895,Balasubramanian Sridhar101145

Affiliation:

1. Green and Medicinal Chemistry Lab

2. Department of Chemistry

3. Osmania University

4. Hyderabad-500 007

5. India

6. Satavahana University

7. Department of Pharmacy

8. Birla Institute of Technology & Science – Pilani

9. Hyderabad-500 078

10. X-ray Crystallography Division

11. CSIR-Indian Institute of Chemical Technology

Abstract

A convenient synthesis of novel prototypes containing the two pharmacophores of chromene and 1,2,3-triazole in a single molecular backbone, were evaluated againstMycobacterium tuberculosisH37Rv strain.

Funder

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference44 articles.

1. World Health Organization , Global tuberculosis report , 2017 , only available online: http://www.who.int/tb/publications/global_report/en

2. World Health Organization , Global tuberculosis report , 2013 , only available online: http://apps.who.int/iris/bitstream/10665/91355/1/9789241564656_eng.pdf

3. Tuberculosis and HIV Co-Infection

4. Strategies against multidrug-resistant tuberculosis

5. Novel 1,2,3-Triazole Derivatives for Use against Mycobacterium tuberculosis H37Rv (ATCC 27294) Strain

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