Tumor pH and intracellular reduction responsive polypeptide nanomedicine with a sheddable PEG corona and a disulfide-cross-linked core-Reference-Cited by-同舟云学术

Tumor pH and intracellular reduction responsive polypeptide nanomedicine with a sheddable PEG corona and a disulfide-cross-linked core

Published:2018 Issue:25 Volume:9 Page:3488-3498
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Ding Yue¹²³⁴⁵,Du Chang¹²³⁴⁵,Qian Jiwen¹²³⁴⁵,Zhou Linzhu¹²³⁴⁵,Su Yue¹²³⁴⁵^ORCID,Zhang Rong⁶⁷⁸⁹⁵,Dong Chang-Ming¹²³⁴⁵^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering

2. Shanghai Key Laboratory of Electrical Insulation and Thermal Aging

3. Shanghai Jiao Tong University

4. Shanghai 200240

5. P. R. China

6. Joint Research Center for Precision Medicine

7. Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus

8. Shanghai Fengxian Central Hospital

9. Shanghai 201400

Abstract

To overcome the tumor and cellular barriers in cancer chemotherapy, a new class of polypeptide copolymer nanoparticles with a sheddable PEG corona and a dynamic disulfide bond cross-linked core was fabricated for intracellular pHe and reduction triggered cytotoxicity.

Funder

National Natural Science Foundation of China

Shanghai Jiao Tong University

Shanghai Municipal Education Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2018/PY/C8PY00579F

Reference51 articles.

1. Polymeric Nanostructures for Imaging and Therapy