Ultrasensitive detection of β-lactamase-associated drug-resistant bacteria using a novel mass-tagged probe-mediated cascaded signal amplification strategy

Author:

Zhu Jianhua1,Bai Yunfei2ORCID,Chen Xiuyu1,Hu Linlin34,Zhang Wenjun1,Liu Chunyan1,Shao Hua3,Sun Jianguo5,Chen Yun167ORCID

Affiliation:

1. School of Pharmacy, Nanjing Medical University, 818 Tian Yuan East Road, Nanjing, 211166, China

2. State Key Laboratory of Bioelectronics, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, 210096 China

3. Department of Pharmacy, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China

4. Office of Clinical Trial Institution, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China

5. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China

6. State Key Laboratory of Reproductive Medicine, 210029, China

7. Key Laboratory of Cardiovascular & Cerebrovascular Medicine, Nanjing, 211166, China

Abstract

Development of a mass-tagged probe-mediated enzyme- and light-assisted cascaded signal amplification strategy for the ultrasensitive detection of β-lactamase.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Jiangsu Provincial Key Research and Development Program

Foundation Research Project of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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