Nanoscale mechanics guides cellular decision making

Author:

Rahil Zainab123,Pedron Sara4563,Wang Xuefeng7893ORCID,Ha TaekJip1011123,Harley Brendan456313,Leckband Deborah12345

Affiliation:

1. Department of Bioengineering

2. Urbana, IL

3. USA

4. Carl R. Woese Institute for Genomic Biology

5. University of Illinois

6. Urbana

7. Department of Physics and Astronomy

8. Iowa State University

9. Ames

10. Department of Physics

11. Johns Hopkins University

12. Baltimore

13. Department of Chemical and Biomolecular Engineering

Abstract

Nanoscale tension gauges revealed how substrate stiffness alters pico Newton force thresholds that trigger initial cell attachment, spreading, and adhesion maturation.

Funder

Division of Physics

National Institutes of Health

Division of Civil, Mechanical and Manufacturing Innovation

National Institute of General Medical Sciences

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

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