Increasing the functional density of threose nucleic acid

Author:

Majumdar Biju1ORCID,Sarma Daisy1ORCID,Yu Yutong1ORCID,Lozoya-Colinas Adriana1ORCID,Chaput John C.1234ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, University of California, Irvine, CA 92697-3958, USA

2. Department of Chemistry, University of California, Irvine, CA 92697-3958, USA

3. Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3958, USA

4. Department of Chemical and Biomolecular Engineering, University of California, Irvine, CA 92697-3958, USA

Abstract

Chemical strategies that augment genetic polymers with amino acid residues that are overrepresented on the paratope surface of an antibody offer a promising route for enhancing the binding properties of nucleic acid aptamers.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

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