Ten-step asymmetric total syntheses of potent antibiotics anthracimycin and anthracimycin B-Reference-Cited by-同舟云学术

Ten-step asymmetric total syntheses of potent antibiotics anthracimycin and anthracimycin B

Published:2022 Issue:43 Volume:13 Page:12776-12781
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tian Peilin¹,Ye Wenkang²,Zhang Xiayan¹,Tong Yi¹,Qian Pei-Yuan²³^ORCID,Tong Rongbiao¹³^ORCID

Affiliation:

1. Department of Chemistry, The Hong Kong University of Science and Technology, Clearwater Bay, Kowloon, Hong Kong, China

2. Department of Ocean Science, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China

3. The Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Nansha, Guangzhou 511458, China

Abstract

A convergent protecting-group free 10-step total synthesis of anthracimycin and anthracimycin B (first) was achieved, featuring cascade vinylogous Mukaiyama Aldol and intramolelucular Diels–Alder reaction and Z-selective ring-closing metathesis.

Funder

Research Grants Council, University Grants Committee

Southern Marine Science and Engineering Guangdong Laboratory

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC05049H

Reference49 articles.

1. A return to the pre-antimicrobial era?

2. Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling

3. Genome Mining for Novel Natural Product Discovery

4. Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The sugar cube: Network control and emergence in stereoediting reactions;Science;2024-07-26

2. Total Synthesis and Stereochemical Assignment of Talaroconvolutin A and Talarofuranone: Gram‐scale Synthesis of Ferroptosis Inducer Talaroconvolutin A;Chinese Journal of Chemistry;2024-03-07

3. Structure revision of lagunamide C to odoamide by total synthesis and biological evaluation;Tetrahedron;2024-03

4. Stereoselective synthesis of an advanced trans-decalin intermediate towards the total synthesis of anthracimycin;Chemical Communications;2024

5. Marine natural products;Natural Product Reports;2024