A versatile biosynthetic approach to amide bond formation-Reference-Cited by-同舟云学术

A versatile biosynthetic approach to amide bond formation

Published:2018 Issue:15 Volume:20 Page:3426-3431
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Philpott Helena K.¹²³⁴⁵,Thomas Pamela J.⁶⁷²³⁴,Tew David¹²³⁴⁵,Fuerst Doug E.¹²⁸⁹,Lovelock Sarah L.¹²³⁴⁵^ORCID

Affiliation:

1. Advanced Manufacturing Technologies

2. GlaxoSmithKline

3. Medicines Research Centre

4. Stevenage

5. UK

6. Molecular Design

7. Computational and Modelling Sciences

8. King of Prussia

9. USA

Abstract

Combining N-acyltransferases and CoA ligases with desired substrate profiles allows the construction of non-natural biosynthetic pathways for the synthesis of structurally diverse secondary and tertiary amides in high yields.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/GC/C8GC01697F

Reference37 articles.

1. The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

2. Amide bond formation: beyond the myth of coupling reagents

3. Key green chemistry research areas—a perspective from pharmaceutical manufacturers

4. Rethinking amide bond synthesis

5. Catalytic amide formation from non-activated carboxylic acids and amines

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