A peptide-based synthetic transcription factor selectively down-regulates the proto-oncogene CFOS in tumour cells and inhibits proliferation-Reference-Cited by-同舟云学术

A peptide-based synthetic transcription factor selectively down-regulates the proto-oncogene CFOS in tumour cells and inhibits proliferation

Published:2017 Issue:2 Volume:53 Page:376-379
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Chakraborty Madhumita¹²³⁴,Roy Siddhartha¹²³⁴

Affiliation:

1. Department of Biophysics

2. Bose Institute

3. Kolkata 700054

4. India

Abstract

A synthetic transcription factor targeted against Elk-1 inhibits expression of CFOS and other genes selectively in Ras-mutated tumour cells.

Funder

Science and Engineering Research Board

Department of Biotechnology , Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C6CC08086C

Reference19 articles.

1. Melanoma genome sequencing reveals frequent PREX2 mutations

2. Activation of gene expression by small molecule transcription factors

3. TRANSCRIPTION FACTORS: Structural Families and Principles of DNA Recognition

4. An orthosteric inhibitor of the Ras-Sos interaction

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