Mouse metallothionein-1 and metallothionein-2 are not biologically interchangeable in an animal model of multiple sclerosis, EAE

Author:

Comes Gemma12345ORCID,Fernandez-Gayol Olaya12345ORCID,Molinero Amalia12345ORCID,Giralt Mercedes12345ORCID,Capdevila Mercè678910ORCID,Atrian Silvia1112131415ORCID,Hidalgo Juan12345ORCID

Affiliation:

1. Animal Physiology Unit

2. C/Vall Moronta s/n

3. Department of Cellular Biology

4. Physiology and Immunology

5. Faculty of Biosciences, and Institute of Neurosciences

6. Departament de Química

7. Facultat de Ciències

8. Universitat Autònoma de Barcelona

9. 08193 Barcelona

10. Spain

11. Departament de Genètica

12. Microbiologia i Estadística and Institut de Recerca de la Biodiversitat (IRBio)

13. Facultat de Biologia

14. Universitat de Barcelona

15. 08028 Barcelona

Abstract

Mice treated daily with MT2 (but not MT1) showed a significant amelioration of the clinical course of experimental autoimmune encephalomyelitis (EAE).

Funder

Ministerio de Economía y Competitividad

European Regional Development Fund

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Reference61 articles.

1. A CADMIUM PROTEIN FROM EQUINE KIDNEY CORTEX

2. J. Hidalgo , R.Chung , M.Penkowa and M.Vašák , in Metallothioneins and related chelators. Metal ions in life sciences , ed. A. Sigel , H. Sigel and R. K. O. Sigel , RSC Publishing , Cambridge , 2009 , vol. 5, pp. 279–317

3. P.-A. Binz and J. H. R.Kägi , in Metallothionein IV , ed. C. D. Klaassen , Birkhäuser , Verlag, Basel , 1999 , pp. 7–13

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