Use of the dehydrophos biosynthetic enzymes to prepare antimicrobial analogs of alaphosphin
Author:
Affiliation:
1. Institute for Genomic Biology
2. University of Illinois at Urbana-Champaign
3. Urbana
4. USA
5. Department of Chemistry
Abstract
An efficient method for preparing phosphonodipeptides, compounds that have potential as clinical antibiotics, is reported using enzymatic catalysis.
Funder
National Institute of General Medical Sciences
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02860E
Reference43 articles.
1. Remarkable Potential of the α-Aminophosphonate/Phosphinate Structural Motif in Medicinal Chemistry
2. Bifunctional antimicrobial conjugates and hybrid antimicrobials
3. Phosphonopeptides as Antibacterial Agents: Mechanism of Action of Alaphosphin
4. Phosphonopeptides as substrates for peptide transport systems and peptidases of Escherichia coli
5. Peptide derivatives as prodrugs
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