Pharmacophore-driven identification of human glutaminyl cyclase inhibitors from foods, plants and herbs unveils the bioactive property and potential of Azaleatin in the treatment of Alzheimer's disease-Reference-Cited by-同舟云学术

Pharmacophore-driven identification of human glutaminyl cyclase inhibitors from foods, plants and herbs unveils the bioactive property and potential of Azaleatin in the treatment of Alzheimer's disease

Published:2022 Issue:24 Volume:13 Page:12632-12647
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Tsai Keng-Chang¹²,Zhang Yi-Xuan³,Kao Hsiang-Yun³,Fung Kit-Man³⁴,Tseng Tien-Sheng³^ORCID

Affiliation:

1. National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan

2. Ph.D. Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

3. Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan

4. Institute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan

Abstract

Alzheimer's disease (AD) is the leading cause of disabilities in old age and a rapidly growing condition in the elderly population.

Funder

Ministry of Science and Technology, Taiwan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D2FO02507H

Reference110 articles.

1. Functional Comparison of Two Human Monocyte Chemotactic Protein-2 Isoforms, Role of the Amino-Terminal Pyroglutamic Acid and Processing by CD26/Dipeptidyl Peptidase IV

2. Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides.

3. An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes.

4. Primary structure and functional expression of a glutaminyl cyclase.

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