A bifunctional old yellow enzyme from Penicillium roqueforti is involved in ergot alkaloid biosynthesis
Author:
Affiliation:
1. Institut für Pharmazeutische Biologie und Biotechnologie
2. Philipps-Universität Marburg
3. D-35037 Marburg
4. Germany
Abstract
Bifunctional FgaOx3Pr3catalyses the formation of festuclavine in the presence of EasG or FgaFS and enhances the activity of several chanoclavine-I dehydrogenases tremendously.
Funder
Deutsche Forschungsgemeinschaft
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB02095C
Reference37 articles.
1. Ergot Alkaloids
2. Pharmacology of Dihydroergotamine and Evidence for Efficacy and Safety in Migraine
3. Ergot: from witchcraft to biotechnology
4. Biosynthetic Pathways of Ergot Alkaloids
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