Biomonitoring of occupational exposure to 5-FU by assaying α-fluoro-β-alanine in urine with a highly sensitive UHPLC-MS/MS method

Author:

Dhersin Alice12345,Atgé Benoît12345,Martinez Béatrice45236,Titier Karine123,Rousset Marine12345,Sidatt Cheikh El Moustaph Mohamed789,Verdun-Esquer Catherine452310,Molimard Mathieu12345,Villa Antoine1112133ORCID,Canal-Raffin Mireille12345ORCID

Affiliation:

1. Laboratoire de Pharmacologie Clinique et Toxicologie

2. 33076 Bordeaux

3. France

4. INSERM U1219

5. Université de Bordeaux

6. Univ. of Bordeaux

7. Ministère de la Santé

8. Nouakchott

9. Mauritanie

10. Service de Médecine du Travail et de Pathologies Professionnelles

11. Consultation de Pathologie Professionnelle

12. GH Fernand Widal-Lariboisière-Saint Louis

13. 75010 Paris

Abstract

5-Fluorouracil (5-FU) is one of the most widely antineoplastic drugs handled by healthcare professionals.

Funder

Conseil Régional d'Auvergne

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Reference37 articles.

1. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

2. S. Amira , Les risques professionnels par métiers. Enquête Sumer, 2010. Direction de l'animation de la recherche, des études et des statistiques (DARES), Synthèse. Stat. , 2014 , vol. 5

3. Preventing Occupational Exposures to Antineoplastic Drugs in Health Care Settings

4. Reproductive Health Risks Associated With Occupational Exposures to Antineoplastic Drugs in Health Care Settings

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