Thymol ameliorated neurotoxicity and cognitive deterioration in a thioacetamide-induced hepatic encephalopathy rat model; involvement of the BDNF/CREB signaling pathway-Reference-Cited by-同舟云学术

Thymol ameliorated neurotoxicity and cognitive deterioration in a thioacetamide-induced hepatic encephalopathy rat model; involvement of the BDNF/CREB signaling pathway

Published:2022 Issue:11 Volume:13 Page:6180-6194
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Ogaly Hanan A.¹²^ORCID,Abdel-Rahman Rehab F.³^ORCID,Mohamed Marawan Abd Elbaset³^ORCID,O.A. Ahmed-Farid⁴,Khattab Marwa S.⁵^ORCID,Abd-Elsalam Reham M.⁵^ORCID

Affiliation:

1. Department of Chemistry, College of Science, King Khalid University, Abha, Saudi Arabia

2. Department of Biochemistry, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt

3. Department of Pharmacology, Medical Research and Clinical Studies Institute, National Research Center, Dokki, Giza, Egypt

4. Department of Physiology, National Organization for Drug Control and Research, Giza, Egypt

5. Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt

Abstract

THY was found to exert hepato- and neuroprotective effects against HE via its antioxidant, anti-inflammatory effects in addition to activation of the CREB/BDNF signaling pathway.

Funder

King Khalid University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D1FO04292K

Reference80 articles.

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2. Therapy of Intracranial Hypertension in Patients With Fulminant Hepatic Failure

3. Pathomechanisms in hepatic encephalopathy