Design, synthesis, and antibacterial evaluation of a novel series of biaryloxazolidinone derivatives against Gram-positive bacteria-Reference-Cited by-同舟云学术

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Design, synthesis, and antibacterial evaluation of a novel series of biaryloxazolidinone derivatives against Gram-positive bacteria

Published:2022 Issue:19 Volume:46 Page:9470-9485
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Qi Yinliang¹,Ding Xiudong²,Wang Kun¹,Yan Pingzhen¹,Guo Xinxin¹,Ma Shiwei¹,Xiao Mingfei¹,Sun Pengrui²,Liu Siyu¹,Hou Yunlei¹^ORCID,Zhao Yanfang¹^ORCID

Affiliation:

1. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, Liaoning, 110016, China

2. Department of Clinical Laboratory, The Eighth Medical Center of PLA General Hospital, Beijing 100091, China

Abstract

A series of new biaryloxazolidinone derivatives has been designed and synthesized using the combination principle and blocking metabolic site to improve their antibacterial activity and stability.

Funder

Program for Liaoning Innovative Talents in University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ00479H

Reference36 articles.

1. Antibacterial drug discovery in the resistance era

2. Antibiotics That Resist Resistance

3. New approaches to overcoming bacterial resistance

4. The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America

5. Identification of Novel Tricyclic Benzo[1,3]oxazinyloxazolidinones as Potent Antibacterial Agents with Excellent Pharmacokinetic Profiles against Drug-Resistant Pathogens

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