Deciphering the selectivity of inhibitor MKC9989 towards residue K907 in IRE1α; a multiscale in silico approach
Author:
Affiliation:
1. Department of Chemistry and Molecular Biology
2. University of Gothenburg
3. 405 30 Göteborg
4. Sweden
Abstract
The high selectivity of inhibitor MKC9989 towards Lys907 of IRE1α is explained by the unique pKa properties of the lysine.
Funder
Vetenskapsrådet
VINNOVA
H2020 Marie Skłodowska-Curie Actions
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA01895C
Reference49 articles.
1. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.
2. XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor
3. A Synthetic Biology Approach Identifies the Mammalian UPR RNA Ligase RtcB
4. The R tc B RNA ligase is an essential component of the metazoan unfolded protein response
5. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
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