Photoisomerization-enhanced 1,3-dipolar cycloaddition of carbon-bridged octocyclic azobenzene with photo-released nitrile imine for peptide stapling and imaging in live cells-Reference-Cited by-同舟云学术

Photoisomerization-enhanced 1,3-dipolar cycloaddition of carbon-bridged octocyclic azobenzene with photo-released nitrile imine for peptide stapling and imaging in live cells

Published:2020 Issue:29 Volume:18 Page:5602-5607
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Deng Jiajie¹²³⁴⁵,Wu Xueting¹²³⁴⁵,Guo Guiling¹²³⁴⁵,Zhao Xiaohu¹²³⁴⁵,Yu Zhipeng¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Green Chemistry and Technology of Ministry of Education

2. College of Chemistry

3. Sichuan University

4. Chengdu 610064

5. China

Abstract

A novel photo-click ligation reaction between nitrile imines and photo-switchable octocyclic azobenzenes was established to both tune the conformation of the NoxaB peptide and conjugate probes with enhanced efficacy in cell apoptosis.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01027H

Reference40 articles.

1. The growing applications of click chemistry

2. Light-Induced Click Reactions