Regulation of microtubule dynamics and function in living cells <i>via</i> cucurbit[7]uril host

Regulation of microtubule dynamics and function in living cells via cucurbit[7]uril host–guest assembly

Published:2024 Issue:30 Volume:15 Page:11981-11994
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Saroha Akshay¹,Bosco Monica Swetha¹,Menon Sneha²,Kumari Pratibha¹,Maity Tanmoy³,Rana Subinoy³^ORCID,Kotak Sachin⁴,Mondal Jagannath²^ORCID,Agasti Sarit S.¹⁵⁶^ORCID

Affiliation:

1. New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka 560064, India

2. Tata Institute of Fundamental Research, 36/P, Gopanpally Village, Hyderabad, 500046, India

3. Materials Research Centre, Indian Institute of Science, C. V. Raman Road, Bangalore 560012, India

4. Department of Microbiology and Cell Biology, Indian Institute of Science, 560012 Bangalore, India

5. Chemistry & Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka 560064, India

6. School of Advanced Materials (SAMat), Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka 560064, India

Abstract

We describe here a reconfigurable supramolecular system based on cucurbit[7]uril (CB[7]) host–guest chemistry to regulate the dynamics and functions of microtubules in living cells.

Funder

Science and Engineering Research Board

Wellcome Trust DBT India Alliance

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC00204K

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