Regulation of microtubule dynamics and function in living cells via cucurbit[7]uril host–guest assembly

Author:

Saroha Akshay1,Bosco Monica Swetha1,Menon Sneha2,Kumari Pratibha1,Maity Tanmoy3,Rana Subinoy3ORCID,Kotak Sachin4,Mondal Jagannath2ORCID,Agasti Sarit S.156ORCID

Affiliation:

1. New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka 560064, India

2. Tata Institute of Fundamental Research, 36/P, Gopanpally Village, Hyderabad, 500046, India

3. Materials Research Centre, Indian Institute of Science, C. V. Raman Road, Bangalore 560012, India

4. Department of Microbiology and Cell Biology, Indian Institute of Science, 560012 Bangalore, India

5. Chemistry & Physics of Materials Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka 560064, India

6. School of Advanced Materials (SAMat), Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka 560064, India

Abstract

We describe here a reconfigurable supramolecular system based on cucurbit[7]uril (CB[7]) host–guest chemistry to regulate the dynamics and functions of microtubules in living cells.

Funder

Science and Engineering Research Board

Wellcome Trust DBT India Alliance

Publisher

Royal Society of Chemistry (RSC)

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